VENUGOPALAN, VINAYA K, YOGITA G, KALPANA J, ARVIND CHOPRA.
CENTER FOR RHEUMATIC DISEASES, INTERDISCIPLINARY SCHOOL
OF HEALTH SCIENCE, UNIVERSITY OF PUNE.
Pauciarticular/oligoarthicular onset arthritis (OLA)
and enthesitis related arthritis (EnA), the two major
groups in the Edmonton ILAR classification 2001 (revised)
of Juvenile Idiopathic Arthritis (JIA), have a strong
association with the Human Leucocyte Antigen (HLA) –
B27 allele. There is sparse data on the prevalence of
HLA-B27 in Indian JIA.
Out of a large cohort of JIA, we chose the initial 64
(M = 57; F = 7) patients with seronegative inflammatory
arthritis for detail evaluation, including HLA-B27 typing.
Systemic arthritis and polyarthritis were excluded.
HLA-B27 testing was done by Amplification Refractory
Mutation System – Polymerase Chain Reaction (ARMS-PCR).
The patients were classified into EnA =49 and OLA=15.
Median age of onset was 13 years and 9.5 years in EnA
and OLA respectively. HLA-B27 was positive in 39 patients
(80%) of EnA and 4 patients (27%) of OLA
We present the overall clinical and immuno-genetic profile
of the subjects in the current study.