of HLA-DRB1 with Rheumatoid Arthritis (RA) in
family Studies:- Familial aggregation of
RA & its association with HLA-DRB1 alleles
is being studied in families where more than 1
degree relatives are being affected with the disease.
In Bhigwan COPCORD study, one such family is being
followed where the disease has affected 3 generations;
more than 8 members in the family have RA. A strong
association with the HLA-DRB1 * 010 has been observed
in this family.?