| Association 
                                of HLA-DRB1 with Rheumatoid Arthritis (RA) in 
                                family Studies:- Familial aggregation of 
                                RA & its association with HLA-DRB1 alleles 
                                is being studied in families where more than 1 
                                degree relatives are being affected with the disease. 
                                In Bhigwan COPCORD study, one such family is being 
                                followed where the disease has affected 3 generations; 
                                more than 8 members in the family have RA. A strong 
                                association with the HLA-DRB1 * 010 has been observed 
                                in this family.?  |