Data
on the burden and pattern of rheumatism and arthritis
in the Indian community is sparse. There are less
than a dozen centers devoted to rheumatology and the
large majority are in the Government sector busy performing
routine patient care. Rheumatism for several reasons
is not a priority with the Health Ministry or with
the Indian Medical Council. Specialists in private
practice rarely if ever contribute to the national
needs of research and measures of disease burden.
In 1996, Center for Rheumatic Diseases (CRD), Pune,
was set up as a research facility on a 1200 sq ft
property by a single rheumatologist in close proximity
to his growing practice with a 3 fold aim -: collect
community data, measure disease burden and explore
Ayurveda-Modern medicine interface for better therapy
solutions.
More
than 6000 patients have been evaluated and served
in over 45 free of cost arthritis camps. The entire
camp methodology has been restructured towards providing
service and simultaneously collecting research data.
For the first time, CRD has used these camps to enroll
volunteer patients into clinical therapeutic trials-
a fast track model with immense saving of time and
money. Driven by economics and a possible future experimental
need, blood and serum of almost every patient from
camp, trial and population study, has been preserved
in a deep freeze. The latter has been a continuous
resource for several laboratory based novel experiments
to define diagnostics and related characteristics
unique to the Indian scenario for several common rheumatic
disorders. The lab projects on the preserved blood
samples have been undertaken as and when funds are
made available. The latter also includes immunogenetics
that has attracted prestigious collaborations with
institutions abroad and exposed patterns different
from the Western World. CRD has simplified several
complex lab methods and further demonstrated that
economical conventional techniques continue to be
as efficient as the expensive modern techniques.
In
a quest to measure disease burden, CRD launched the
WHO maiden COPCORD (Community oriented program for
control of rheumatic diseases) for India in a 9000+
population of village
Bhigwan (Pune District) (100 kms from Pune enroute
to Sholapur). Begun in 1996 and in its tenth operational
year, COPCORD Bhigwan has generated robust prevalence
and incidence data that has been globally presented
and published. Though initiated in several countries,
COPCORD Bhigwan is the only ongoing planned program
in the World serving the original WHO doctrine. While
launching the UN endorsed ‘The Bone and Joint
Decade (BJD)’, WHO adopted the COPCORD Bhigwan
model to project the rheumatic disease burden for
South East Asia. However, the success of this Bhigwan
population study has been due to the novel and indigenous
fast tract study model that to begin with was largely
dictated by the concerns and demands of the Bhigwan
villagers- the model is a significant variation of
the conventional WHO model for the purpose and the
core questionnaires etc are modified to suit the Indian
conditions. Modifications include validated questionnaires
to measure functional disability in arthritis in Indian
patients. The COPCORD Bhigwan has been totally free
of cost to the local population. Further, in 2003,
BJD India adopted the CRD’s COPCORD Bhigwan
model to launch several urban population surveys to
collect national data for rheumatic diseases -begun
in Jammu, Chennai and Pune. The population and camps’
data is continuously fed into a user friendly statistically
worthy secure data base, indigenously created and
maintained by CRD personnel. In fact, dedicated personnel
write exclusive soft ware programs for every major
research project. Along with epidemiology, CRD has
also developed feasible and economical drug trial
protocols to evaluate the efficacy and safety of standardized
Ayurvedic formulations. In conjunction with Ayurvedic
faculty, several potential promising antiarthritic
formulations have been tested in over 12 World class
trials, several of which have been published in top
class peer reviewed medical journals.
CRD
is the principle clinical co-ordination center for
the CSIR,GOI, NMITLI arthritis project 2002-2006 involving
several national research facilities such as Pune
Univ, AIIMS (Delhi), RRL (Jammu), NIBR (Lucknow),
etc. CRD is recognized as a research institute by
the Pune Univ and a ‘SIRO’ by the DSIR,
GOI. Since 2002, the activities of CRD are administered
by the ‘Arthritis Research Care Foundation’,
a registered research Society/Trust set up by senior
patrons with a personal interest in alleviating the
pain and suffering of rheumatism and arthritis patients.
Today, CRD is manned by 18 personnel which includes
4 specialist physicians. Since inception, CRD has
been financially managed exclusively by the concurrent
private referral practice of its founder and some
of the funded research projects, and no donation has
been ever accepted from the pharmaceutics or the community
for its various research projects. The COPCORD Bhigwan
project has been completely sustained by the CRD till
date.