ANURADHA VENUGOPALAN, ARVIND CHOPRA,
SENGUPTA A, SALUJA M, PATIL J
CENTER FOR RHEUMATIC DISEASES, PUNE, INDIA.
Hospital-based studies of Indian patients of RA have
described relatively low RF seropositivity. Population
studies, especially rural, are sparse.
* Partly funded by a seed grant
To evaluate the significance of RF in the COPCORD rural
774 cases of rheumatic musculoskeletal (RMS) pains were
identified in Stage I census survey (N = 4092) of the
maiden Indian COPCORD in village
Bhigwan (Pune District) (APLAR J Rheumatol 1997,V1:145-154;
J Rheumatol 2002,V29:614-621).RF was tested by latex
agglutination (cut off positive at ? 80 IU/ML) in 216
patients of polyarthralgias [RA = 27; Unclassifiable
Inflammatory Arthritis(IA-U) = 24; Non-Inflammatory
Arthritis (NIA) = 165 (OA = 65; Soft tissue rheumatism=100)]
and 103 healthy controls (HC) from the village (age
: 25 – 55 yrs.).All patients suspected to be suffering
from inflammatory PA were tested. Patients of RA and
OA were classified as per ACR.
In the RA group (Females=22, Males=5), 11(41%) patients
were seropositive (range:160 – 640 IU/ML; mean :
247 IU/ML). Erosive arthritis was evident in skiagrams
(hands and/or feet) in 13(48%) patients; Only 4 (31%)
were seropositive. 2(1.2%) patients of NIA were seropositive(range
320– 640 IU/ML; mean:453 IU/ML), 4 (3.9%) HC were
seropositive(range : 80 – 160 IU/ML). The specificity
of RF for RA was found to be 100% (versus IA-U); 98% (versus
NIA) and 96% (versus HC).
The low sensitivity of RF (41%) in RA in this rural
COPCORD is consistent with many population surveys from
different parts of the world. The high specificity of
RF in our study is rather reassuring.
FOR RHEUMATIC DISEASES (CRD)
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